منابع مشابه
Tumor Immunity
In a consideration of tumor immunity it appears desirable to discuss resistance to spontaneous tumors and to implanted tumor separately. Although results obtained with experimentally implanted tumors have contributed to the biology of tumors, these results can not be applied directly to spontaneous tumors and this is especially true with respect to immunity. It has long been recognized that imm...
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The remarkable capacity of the immune system to distinguish self from non-self makes it almost impossible to transmit cancers (or organs) from one individual to another in the absence of immunosuppressive drugs. Whereas rejection of donor cells bearing mismatched MHC alleles has been ascribed to direct activation of T cells by the altered MHC-peptide structures, the factors that initiate reject...
متن کاملTumor transplantation and tumor immunity: a personal view.
quarters of a century ago (2). It has often been remarked that the workers in these fields have suffered from manic-depressive waves of optimism and pessimism (3), and an attempt will be made to trace the causes of this instability. Why have scientists held certain views with such violence, only to see their position overturned and, if they lived long enough, overturned again? A general explana...
متن کاملRUNX3 methylation and anti-tumor immunity.
Altered DNA methylation is a hallmark of cancer genomes and has been advocated as both a marker and mechanism of the malignant phenotype. In the conventional view, such alterations include global DNA hypomethylation, linked to aberrant expression of oncogenic driver genes and more localised de novo hypermethylation at ‘CpG-island’ promoters, argued to cause inappropriate silencing of tumor supp...
متن کاملTumor reductive therapies and antitumor immunity
Tumor reductive therapy is to reduce tumor burden through direct killing of tumor cells. So far, there is no report on the connection between antitumor immunity and tumor reductive therapies. In the last few years, a new category of cancer treatment, immunotherapy, emerged and they are categorized separately from classic cytotoxic treatments (chemo and radiation therapy). The most prominent exa...
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ژورنال
عنوان ژورنال: Medicina
سال: 2009
ISSN: 1648-9144
DOI: 10.3390/medicina45020021